

Qualls also appeared as a Y2K prophet opposite Rami Malek in the sci-fi mystery thriller Buster's Mal Heart (2017). In 2001, he played Neil Lawrence in Chasing Holden. In Cherry Falls (2000), he played Wally, another virgin. After this, he worked as a model for Prada and photographers such as David LaChapelle and Steve Klein.

He debuted in Road Trip as shy virgin Kyle Edwards. After auditioning for a one-liner in Road Trip (2000), he was asked to come from the Atlanta office to meet producer Ivan Reitman in California. He landed the small role of Jason in the miniseries Mama Flora's Family (1998) while participating in community theater. Qualls was an extra in the 1994 HBO film Against the Wall. He returned to Tennessee, enrolling at Belmont University in Nashville, where he also began acting in a local theater company. After graduating from Coffee County Central High School in 1995, where he was an active member in the Red Raider Band, Qualls attended King's College London, where he studied English literature. According to Qualls, the chemotherapy at an early age sped up his metabolism and impacted his growth, "It stopped my development," which explains his slender frame.

After two years of treatment, his cancer was said to be in remission. He was diagnosed with Hodgkin's lymphoma at age fourteen. He was raised in Manchester, Tennessee, and attended school in nearby Tullahoma. Qualls was born in Nashville, Tennessee, one of five children of Donnie and Janice Qualls.
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He co-starred in the FX comedy series Legit, the Syfy horror series Z Nation and the Amazon Studios show The Man in the High Castle. He is best known for his work in films including Road Trip (2000), The New Guy (2002) and The Core (2003), and for several appearances on television series such as Breaking Bad, Supernatural, Scrubs, Lost, CSI: Crime Scene Investigation. Donald Joseph Qualls (born June 10, 1978) is an American actor.
